Abstract: Nanling mountains area in northern Guangdong Province is the main water conservation area in the Pearl River Delta region of China and an important ecological barrier in South China. Based on the concept of “mountain-river-forest-farmland-lake-grassland (MRFFLG) system is a life community”, in view of the eco-environment problems of mine and soil environment, water conservation and biodiversity protection, basin water environment protection and management, environmental security guarantee and ecological development, the ecological protection and restoration goals of green hills and clear waters, surrounded by forest belts, green lakes and fields, beautiful city and human conditions were proposed. Based on the premise of spatial control and with the general ideas of overall protection, system restoration, comprehensive treatment and emphasizing problem’s guidance, the corresponding 17 projects in four categories were designed. Since the implementation of the program, it had achieved remarkable results in the aspects of recovering the mine eco-environment, improving the safe utilization rate of cultivated land, stabilizing the standard rate of drinking water quality, enhancing the stability of regional ecosystem and improving the ecological environment. It was suggested that the following research should be focused on analyzing the difference characteristics of ecological elements of the MRFFLG system, improving the spatial allocation of natural resource elements and ecological compensation mechanism, summarizing pilot experiences and exploring new management and operation models.