Abstract: Tannery wastewater has the characteristics of large amount of production, various types of pollutants, complex composition, and containing heavy metals, and has always been the focus of water environment supervision. The tannery production process and the characteristics of wastewater production and discharge were sorted out, and the mainstream water pollution prevention and control technologies in the industry were summarized according to the raw and auxiliary material substitution technology, process control technology, and end treatment technology. Among them, the process control technologies were classified based on target pollutants, and the end treatment technologies were classified according to the requirements of wastewater quality-specific treatment. Based on the various demands for water pollution prevention and control of tannery enterprises with different production processes and different discharge types, 16 sets of technology portfolio were recommended. Finally, the development trend of water pollution prevention and control technologies of the tanning industry was prospected, and suggestions to strengthen the quality-specific treatment of tannery wastewater, strengthen the R&D and promotion of cleaner production technologies, and promote the entry of tannery enterprises into the industrial parks were put forward, with a view to improving the level of water pollution whole-process prevention and control and the green development of the industry, and helping to deepen the fight against pollution prevention and control battle during the 14th Five-Year Plan period.