Abstract: To explore the rules of pollutant migration/deposition in the membrane filtration process, a set of mathematical models conforming to the actual filtration process was introduced. By integrating existing mathematical models and analyzing their respective and common limitations, combining various existing research methods to establish ideas, the concept of the "Unsteady Membrane Clogging Model Fitting Test Method" was put forward to deeply analyze the distribution of pollutants in different spaces inside the membrane module at different times during the membrane filtration process, and to realize the continuity of the whole process of the membrane filtration process and membrane clogging mechanism. In this way, the problem of pollutant deposition on the different trapping layers inside the membrane module could be solved more targetedly. At the same time, the model optimization technology was proposed to provide a theoretical basis for model establishment and refinement.