Abstract: In order to solve the problems of the lacking of industry-level research and imperfect screening technology for priority control pollutants, the comprehensive evaluation method, Hasse diagram method and analytic hierarchy process were integrated to form a comprehensive screening technology combining vector analysis and scalar analysis, according to the concepts of cleaner production and whole-process control, and based on the previous researches on the screening technology of the industrial priority control pollutants list. Then, the screening technology was applied in the printed circuit board (PCB) industry in Changzhou City. The results showed that after the whole process investigation and analysis of water samples by gas chromatography-mass spectrometry with 90% matching degree, the list of characteristic pollutants in PCB industry contained 172 substances. There were 30 kinds of substances in the list of priority control pollutants in PCB industry, including 3 kinds of halogenated hydrocarbons, 9 kinds of benzene series, 3 kinds of esters, 1 kind of aldehydes, 5 kinds of alcohols, 2 kinds of ketones, 5 kinds of metal ions, 1 kinds of salts and 1 kind of others. The proposed comprehensive screening technology could be used for the industry so as to obtain the list of pollutants under priority control in PCB industry in the city more scientifically and effectively.