Abstract: In order to solve the problems of high water consumption and high intensity of water pollution discharge in industrial parks, it is necessary to optimize the water resources network of the parks as a whole to realize the efficient use of water resources. Based on the mathematical planning method, considering the differences in water consumption, discharge volume and water quality among the enterprises in the parks and taking into account the economic and environmental factors, a water network optimization mathematical model including water source, treatment unit and water trap was constructed to form an indirect recycling optimization method of water resources applicable to industrial parks. Based on the water network optimization model, the freshwater demand, wastewater discharge and total cost under different scenarios with the objective of minimum freshwater demand in a typical industrial park were compared. The research results showed that the adoption of the indirect recycling water network optimization scheme could reduce the total freshwater demand by 24.7%, reduce wastewater discharge by 40.5%, and increase wastewater reuse rate by 40.5%, and the total cost was moderate at 4.860 9 million yuan/a, which had high environmental benefits. The optimization model could significantly improve the efficiency of water resource utilization in industrial parks.