Abstract: Exploring the coordination status and evolution law of development intensity and habitat quality in the integrated region of the Yangtze River Delta has important enlightenment significance for formulating or revising the regulation strategy of ecological green integration and high-quality development. Based on Landsat satellite remote sensing land use, the data were interpreted and counted. By using In VEST model and principal component analysis comprehensive evaluation method, the habitat quality and development intensity in the integrated region of the Yangtze River Delta from 2005 to 2020 were calculated. The coupling coordination model was used to investigate the coordination between them. The evolution law between them was explored by curve regression analysis. The results showed as follows: The development intensity index of the integrated region of the Yangtze River Delta increased from 0.383 3 in 2005 to 0.783 3 in 2020, and the habitat quality index decreased from 0.504 9 in 2005 to 0.493 7. The coordination degree between the two increased from 0.663 3 in 2005 to 0.788 6 in 2020, and the multi-year average was 0.734 7, which was in a moderate coordination state. The relationship between them was a quadratic parabola with the opening upward. During the 14th Five-year Plan period, its trajectory was still in the left half of the parabola. The contradiction between development intensity and habitat quality would be further intensified. Therefore, ecological green integration and high-quality development would face great challenges.