Abstract: In order to explore the impact of urban spatial development on NO pollution in Wuchangshi Metropolitan Area, the center of gravity of the north slope of Tianshan Mountain Economic Belt, multi-source remote sensing data was used to study the temporal and spatial variation of NO emissions in Wuchangshi Metropolitan Area. The results show that: based on the OMI remote sensing data from 2006 to 2020, according to the average amount of NO₂ emission in Xinjiang, it is found that the low emission zone of NO₂ in Xinjiang is Hotan and other small cities; the low emission zone is Kashgar and Hami and other regions; the medium emission zone 1 is in the western part of Xinjiang; the second high emission zone appears in the middle of Bayingoleng Mongolian Autonomous Prefecture, a medium-sized city on the southern slope, and the high pollution emission zone In the Wuchangshi Metropolitan Area. In terms of spatial pattern, the urban land and construction land are growing with one city and five urban districts of Urumqi as the main center, and Changji City, Fukang City and Shihezi City as the sub-centers. The urbanization process of Wuchangshi Metropolitan Area is accelerated, and the closer it is to the urban area, the more N. The higher the concentration, the higher the degree of pollution to the surrounding environment. During the second management in Wuchangshi Metropolitan Area, the concentration of NO decreased the most. The potential source contribution factor (PSCF) and concentration weight locus (CWT) of Wuchangshi Metropolitan Area were analyzed before and after the critical period of novel coronavirus (2019-2021). The results showed that the main potential source areas were the local region of Urumqi and the neighboring cities in the southwest of Changji Hui Autonomous Prefecture.