Abstract: Pharmaceuticals and personal care products (PPCPs), as a class of typical new pollutants, are often detected in the water environment due to their widespread use and pseudo-persistence, which has aroused worldwide attention. Sediments are important environmental repositories of PPCPs, and polluted sediments can be regarded as long-term pollution sources to cause the pollution of the overlying water. The research results at home and abroad in recent years were reviewed, the occurrence of PPCPs in typical surface water and sediment in seven regions of China were analyzed, and the effects of PPCPs characteristics, sediment components and environmental factors on the interaction migration of PPCPs in water-sediment system were summarized. The results showed as follows:1) The concentration of PPCPs detected in surface water in China ranged from undetected (ND) to 9 785 ng/L. There were 20 kinds of PPCPs with high detection rates and concentrations. The highest concentration was with caffeine (CAF), a non-antibiotic drug, followed by erythromycin (ETM) and sulfamethoxazole (SMX). PPCPs with the highest pollution concentration in the surface water of seven regions of China were non-antibiotic stimulants, which were highly polluted in North China, South China, and Southwest and Northwest, followed by macrolides and sulfonamides in antibiotics which were highly polluted in Northeast, East China and Central China. The highest level of PPCPs pollution in surface water was found in North China, followed by East China. 2) The concentration of PPCPs detected in sediments in China was ND-3 440 ng/g. There were 18 kinds of PPCPs with high detection rates and concentrations, among which triclocarban (TCC) had the highest concentration, followed by oxytetracycline (OTC) and norfloxacin (NOR). PPCPs with the highest pollution concentration in the sediments of seven regions of China were personal care antibacterial agents, with the highest pollution degree in South China, followed by tetracycline and quinolones. Tetracycline pollution degree was higher in East China, Central China and Northeast, and quinolones pollution degree was higher in north China, Northwest and Southwest. The pollution degree of PPCPs in sediments in South China was the highest, followed by East China. 3) PPCPs concentrations in surface water and sediments in China were at a higher level worldwide. The interaction migration of water-sediment system was mainly affected by the nature of PPCPs and sediment components, and the interaction migration mechanism of PPCPs under the coupling effect of sediment components and water environment conditions needed to be further clarified.