Abstract: From the view of engineering practices at home and abroad, the reuse of heavily polluted and complex post-remediation site often poses safety risks to human health, ecological environment or engineering construction. Long-term stewardship is the core strategy to ensure the safe reuse of post-remediation sites. However, relevant studies in this field are still insufficient in China. Based on the statistical analysis of 550 cases of contaminated sites in China, the results showed that 58.7% of post-remediation sites were redeveloped for residential purposes. Two typical safety risk problems, including heavy metal re-release after solidification/stabilization and vapor intrusion of organic pollutants, were analyzed. Based on foreign advanced long-term stewardship experience and domestic practices, suggestions for long-term stewardship and improvement of the above typical safety risks were put forward from five aspects, including long-term monitoring, institutional control, regular review, public participation and site archives management.