Abstract: In order to build safe and tough ecological space, improve the quality and stability of the ecosystem, and enhance the self-recovery capability of ecological space, Inner Mongolia Autonomous Region was taken as an example to study the ecological restoration zoning methods suitable for large-scale space. In response to typical ecosystem issues in the region, an ecosystem evaluation technical system with the combination of "damage-resilience-restoration potential" was built. By evaluating the current status and damage of the ecosystem, the ecosystem problems and degradation areas were identified. According to the characteristics and support capabilities of the ecosystem, the evaluation of ecosystem resilience and restoration potential was carried out. Coupling multi-level evaluation results, the areas with the same restoration characteristics were identified, and ecological space restoration zones were comprehensively defined. The results showed that the areas with high restoration potential were mainly distributed in areas such as Daxing'an Ridge, Yin Mountain, and Helan Mountain. The areas with medium potential mainly included Hulunbuel meadow grassland, Xilin Guole typical grassland, the northern desert grassland of Yin Mountain, and the Alashan desert, etc. The areas with low potential mainly included Xiliao River Basin, the Yellow River basin, the local grassland, and the desert sand areas. Combined with regional characteristics, 9 ecological space restoration zones were comprehensively defined. From the perspective of promoting the structure, quality, functional protection and restoration of the ecosystem, ecological restoration strategies of protection and conservation, natural recovery, auxiliary restoration, and ecological reshaping were proposed according to local conditions, to ensure that the regional ecosystem realized virtuous circulation and self-regulation. Starting from the three levels of ecosystem damage, resilience and restoration potential, an ecological evaluation technical system was established, the ecological space restoration zones was delineated, and methods and implementation paths suitable for large-scale ecological space governance were proposed.