Abstract: Slurry bioreactors are widely used in bioremediation of soils polluted by refractory organic matter because of their fast mass transfer, controllable conditions and high remediation efficiency. The main removal mechanisms of solid-liquid mass transfer, gas-liquid mass transfer and biodegradation involved in the bioremediation of refractory organic matter in slurry bioreactor were reviewed, and the importance of three removal mechanisms, namely solid-liquid mass transfer, gas-liquid mass transfer and biodegradation, was summarized. The research progress of bioreactor modeling at home and abroad was summarized, and the basic models of solid-liquid mass transfer, gas-liquid mass transfer and biodegradation processes were formed. The important parameters of the slurry bioreactor were determined, including physical parameters, biological parameters and operating parameters, and the influence mechanism of various parameters and their suitable range were summarized. Finally, the future research directions of slurry bioreactor to remove refractory organic matter were prospected, including mechanism research, microbial agents, and intelligent application equipment.