Abstract: In order to realize efficient, safe incineration of medical waste, meeting with the environmental standards, the design calculation for the main incineration process supporting equipment (including primary combustion chamber and secondary combustion chamber) was carried out and the design parameters were reviewed. Sawdust and wood blocks were used as substrates for test waste. The parameters of the incineration process, including hydrogen chloride removal rate, heavy metal mercury removal rate, combustion efficiency, residual heat removal rate, soot removal rate, dioxin emission concentration, and overall system performance score, were studied. The volumes of the primary combustion chamber and secondary combustion chamber were determined using methods of thermal engineering theory. Performance metrics were monitored during the incineration process, and correlation analysis was conducted using SPSS 22. The results showed that the volumes of the primary combustion chamber and secondary combustion chamber were inversely calculated as 1.20 and 3.30 m³, respectively, both of which were smaller than the actual furnace volume and met the requirements. The performance score exhibited a strong positive correlation with the removal rates of hydrogen chloride, heavy metal mercury, soot, and combustion efficiency (R=0.965, 0.966, 0.982, 0.997, respectively). Conversely, the performance score was significantly negatively correlated with thermal degradation rate (R=−0.986) and dioxin emission concentration (R=−0.957).