Abstract: The research on the evaluation index system of cleaner production is of great significance for various industries to further promote cleaner production. A cleaner production evaluation framework model for the whole process of “pollution source control-process emission reduction-end treatment-recycling” suitable for general industries was put forward. The evaluation index system of cleaner production in electrolytic manganese industry was constructed, which was composed of 9 first-level indicators such as production process and equipment, and 45 second-level indicators. Expert consultation and analytic hierarchy process were used to determine the index weights, and among them, the weights of harmless treatment rate and direct current consumption index of electrolytic manganese slag were 0.092 and 0.050, respectively, which reflected the emphasis and key points of cleaner production in the industry. The evaluation results of the cleaner production level of three typical enterprises showed that the score of the case enterprises was 40.78-77.26, which was lower than the Ⅰ-level of cleaner production. The index system can effectively reflect the cleaner production level of electrolytic manganese enterprises. Combined with the actual condition of Enterprise 1, 10 targeted cleaner production transformation measures were proposed from the aspects of production process and equipment and so on, which could provide a feasible reference for enterprises to promote cleaner production, and also provide a basis for the formulation of green and low-carbon policies in the industry.