Abstract: The COVID-19 pandemic has caused a rise in face mask demand, and the waste face masks without proper treatment entering the aquatic systems will release dissolved substances, however no effort has been devoted toward systemically exploring the composition and structure, as well as the leaching process of face masks as plastic-based manufacture-derived dissolved substance (PDS) in aquatic environments. Three types of face masks were taken to carry out the leaching experiments. The structure and properties of PDS were analyzed by 3DEEMs coupling with FRI and PARAFAC, and the leaching kinetic model of PDS from plastic-based manufacture was established. The concentration increased for the PDS from three types of face masks with a leaching time of 1~360 h measured in terms of dissolved organic carbon, and the concentration of PDS exhibited two stages with a leaching time, including a rapid increase at the early leaching stage of 0-72 h, and a plateau at the later leaching stage of 72-360 h. The PDS from three types of face masks mainly included tyrosine-like materials, tryptophan-like materials, as well as humic-like materials, in which tyrosine-like materials and tryptophan-like materials were the main constituents, accounting for more than 80%. After the leaching experiment equilibrium (360 h) the fluorescence response percentage of tyrosine-like substances was 1.1-1.7 times that of tryptophan-like substances, indicating that the dissolution of tyrosine-like substances was greater than that of tryptophan-like substances. By using the kinetic models of leaching experiments, the first-order kinetic model ( R_\mathrmadj^2 0.958-0.992) was suitable for the leaching process of PDS from three types of face masks. The leaching rate constants ranged from 0.15-0.43, the half-life ranged from 1.61-4.65 h and the maximum leaching ratio ranged from 0.2‰-0.4‰ for three PDS samples, providing the direct data for the investigation on environmental degradation of emerging contaminants such as plastic and the environmental behavior of PDS, and providing a reference for the control and treatment of emerging contaminants such as plastic.