Abstract: The prevalence of fugitive dust emission with intense shear and high concentration in working environments, such as docks and mines, poses a great challenge to the management of dust pollution. Taking the dust pollution control of coal discharge of a ship unloader along the river in Zhenjiang City as the object, a numerical model for fugitive dust motion was established, and the dynamic evolution process of dusty airflow field and particle trajectory was simulated. The airflow guide coupled water mist dust suppression solution was proposed. An experimental system of airflow guide coupled water mist dust suppression was set up. The experimental study included airflow velocity, droplet size, and transport distance for spray, as well as their influence on dust suppression efficiency. The results showed that the empirical formula for the jet velocity of the double rectangular nozzle air curtain dust suppression system was V/V₀=0.93×exp(−L/1.42)+0.07. The effect of air curtain flow on the transport distance of spray was much greater than that of changing the nozzle spray parameters. The installation position and inclination angle of the nozzle had a significant influence on the transport distance of spray by using Bernoulli effect of the wind curtain airflow. The dust suppression system of airflow guide coupled water mist was applied in the dock ship unloader and achieved a favorable dust suppression effect.