Abstract: To address the problems of refractory organic matter and poor biodegradability in dyeing wastewater, this study used an ultrasound (US)-enhanced Fenton-like system to treat the simulated wastewater containing Methyl Violet 6B dye. A US-enhanced multi-metal ion synergistic Fenton-like degradation system was constructed to investigate the synergistic relationship between ultrasound and metal ions. A combination of single-factor experiments and Box-Behnken response surface method (RSM) was adopted: Firstly, the influence of each parameter was preliminarily investigated through single-factor experiments. Then, the Box-Behnken response surface design was adopted to optimize the key parameters (the dosages of H₂O₂, Fe²⁺, Cu²⁺, and Mn²⁺), and the accuracy of the quadratic polynomial regression model was verified through validation experiments. The results demonstrated that the combination of ultrasound and Fenton (or Fenton-like) reactions had a good synergistic effect (synergistic index S>1). Based on response surface analysis, a regression model of the influencing factors was established, confirming that the US-Fenton or Fenton-like process can accelerate the degradation of simulated dye wastewater. The model predicted the optimal conditions for the degradation of methyl violet (initial concentration of 10 mg/L) as follows: the dosage of H₂O₂ was 17.1 mg/L, the dosage of Fe²⁺ was 26.6 mg/L, the dosage of Cu²⁺ was 3.6 mg/L, and the dosage of Mn²⁺ was 7.6 mg/L. The average removal rate of the verification experiment was 99.74%, which was close to the predicted value of the quadratic polynomial model. The optimized ultrasound-multimetal ion synergistic Fenton-like process demonstrates high degradation capabilities for treating organic dye wastewater, thus providing foundational experimental data and technical reference for the treatment of organic dye wastewater.