Abstract: To address the issues of low ozone mass transfer efficiency and unstable catalytic performance in traditional ozone-catalysis systems, an advanced treatment system utilizing enhanced ozone dissolution coupled with catalytic oxidation was developed. A pilot-scale study was subsequently conducted for treating pesticide wastewater in an industrial park in Jiangsu Province. The results demonstrated that, compared with conventional aeration, the developed system significantly improved ozone mass transfer and free radical conversion efficiency, increasing the COD removal rate from 15.2% to 38.8%. Through parameter optimization, the most cost-effective operation was achieved under the recirculation mode with a hydraulic retention time of 0.5 h and an ozone concentration of 62.5 mg/L, reducing the treatment cost to merely ¥0.64 per ton. Performance evaluation under the series operation mode confirmed that the system not only achieved high-efficiency gas dissolution but also enabled a dual-enhanced removal of organic pollutants during both the dissolution and reactor stages. Furthermore, three-dimensional fluorescence and acute toxicity analyses indicated the system effectively removed fulvic-like substances and reduced biological toxicity. This study provides reliable parameters and practical support for the engineering application of catalytic ozone oxidation in the advanced treatment of pesticide wastewater.