Abstract: Chemical risk assessment is the core scientific basis and main technical approach of chemical management, and establishing chemical risk assessment system is of great importance to China. The international progress and experience on establishment of regulation and system and development of guidance, models and databases of chemical risk assessment system were summarized. The achievements and problems of system establishment, guidelines and standards formulation, scientific research and information gathering in chemical risk assessment in China were analyzed, and the suggestions on legislation establishment, technical system development, basic capacity building, survey and monitoring improvement to establish chemical risk assessment system in China given.