Abstract: The oxidative degradation of amantadine by Fenton reagents was investigated to study the removal efficiency under different conditions to determine the optimum conditions. The results showed that when the amantadine at concentration of 500 mg/L was oxidized by Fenton reaction, the COD_Cr removal rate was around 30%-80% with good treatment effect. The ratio of BOD₅ to COD_Cr increased from zero to around 0.1-0.4. The optimal conditions obtained were as follows: pH was 4-5, reaction time was 15 min, H₂O₂ was 3 000 mg/L and the mass ratio of H₂O₂ to Fe²⁺ was around 1.28. The intermediates analysis of amantadine oxidized by Fenton reagents showed that there was no amantadine detected in the reaction system after 5 min of reaction. After 30 min of reaction, almost all the intermediates were degraded completely.