Abstract: The NO₂ columns density derived from OMI(Ozone Monitoring Instrument) observations was used to study the trend and monthly variability of The NO₂ column density derived from ozone monitoring instrument (OMI) observations was used to study the trend and monthly variability of China as a whole and Beijing, Lanzhou, Shanghai, Chongqing and Guangzhou cities. The findings indicated that increasing trend of NO₂ column density was obvious in recent eight years especially after the 12th Five-year Plan period. There existed obvious periodic characteristics for each city's NO₂ column density and the monthly variability of temporal mean sea level pressure was one of the main reasons of obvious increasing of regional and urban NO₂ column density. Based on the polluting sources of NO₂ in Beijing, Shanghai, Chongqing and Tianjin, the sector difference of the sources in each city was analyzed, and it was pointed out that one effective way to control the NO₂ pollution is to combine the weather pattern and the characteristics of NO₂ emission sources.