Abstract: The Good Laboratory Practice (GLP) development for testing of industrial chemicals in China was reviewed and the outlines of MEP and CNCA GLP systems introduced. Comparing the two GLP systems with OECD GLP Principles, the similarities and differences were discussed. The Chinese term of GLP by MEP and its issues were also interpreted. In order to improve the data quality and integrity for environmental management of chemicals, the MEP GLP system covers all contents of OECD GLP Principles in management system. Additionally, MEP GLP emphasizes the laboratory’s technical capacity, and inserts the technical assessment requirements into its GLP. The problems and challenges on establishment, understanding and implementation of GLP in test facilities of industrial chemicals were analyzed. It is suggested to accentuate laboratory training and its efficiency, increase international communication and bring up a fine set of GLP experts, and improve GLP monitoring systems. It is also proposed to improve laboratory’s technical capacity and management level by inter-laboratory competency comparison and laboratory supervision in compliance with the GLP regulations.