多溴联苯醚与四溴双酚A的生物代谢研究进展

Biological Metabolic Transformation of Polybrominated Diphenyl Ethers and Tetrabromobisphenol A

摘要: 分析了生物体内多溴联苯醚（PBDEs）和四溴双酚A（TBBPA）的来源和分布，综述了PBDEs和TBBPA在生物体内发生还原代谢和氧化代谢的研究进展,从体内原位代谢和体外模拟代谢2个方面探讨了PBDEs和TBBPA的生物代谢机制、代谢途径及代谢中可能涉及的代谢酶，指出今后应进一步深入开展PBDEs和TBBPA的生物积累和代谢产物的定量分析的研究。

Abstract: The distributions and sources of PBDEs and TBBPA in organism were analyzed, and the research progresses of reduction and oxidation metabolism of PBDEs and TBBPA in organisms were reviewed. The metabolism, pathways, and key enzymes involved in the biotransformation of them both in vivo and in vitro were explored. Directions for further studies on the bioaccumulation and biotransformation of PBDEs and TBBPA were proposed.