Abstract: Several commonly used ion exchange resins were compared and the optimal resins to absorb perchlorate were screened out. It showed that Cl717 anion exchange resin acquired the best adsorption efficiency. The adsorption process attributed to the pseudo second order kinetics model, and the equilibrium isotherm for perchlorate uptake corresponded closely to the Langmuir model, belonging to the adsorption type of single layer. The increase of temperature and dosage was beneficial to the adsorption. Co-existed anions could affect the adsorption process with the interference order of Cl^-3^-4^2-4^3-. The best regeneration efficiency was obtained when the concentration of regenerated solution was 2.16 mol/L and the amount of regenerated solution was 5 times of the resin volume. The FTIR analysis revealed that the mechanism of resin absorbing perchlorate was probably the attraction of resin skeleton electrostatic and the formation of hydrogen bond between perchlorate and resin quaternary amine groups.