Abstract: The United States is one of the first countries to carry out study on hazardous air pollutants (HAPs). It has perfect systems of laws, regulations and technical methods, having achieved a comprehensive and effective control and management of hazardous pollutants in the air. In particular, the United States Clean Air Act proposes to establish the list of HAPs and 189 HAPs have been screened out based on the scientific and practical methods. The HAPs are targeted for the prevention and control through management instruments of pollution source management and maximum achievable control limits. The methods of screening the HAPs in the cataloging and the administrative measures for the implementation of the list can provide experience for China to establish its own list of toxic and hazardous air pollutants, so as to provide important basis for air pollution control in the country.