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汞、镉、铅、砷单一和混合暴露的毒性效应及机理研究进展

曾晨 郭少娟 杨立新

曾晨, 郭少娟, 杨立新. 汞、镉、铅、砷单一和混合暴露的毒性效应及机理研究进展[J]. 环境工程技术学报, 2018, 8(2): 221-230. doi: 10.3969/j.issn.1674-991X.2018.02.030
引用本文: 曾晨, 郭少娟, 杨立新. 汞、镉、铅、砷单一和混合暴露的毒性效应及机理研究进展[J]. 环境工程技术学报, 2018, 8(2): 221-230. doi: 10.3969/j.issn.1674-991X.2018.02.030
ZENG Chen, GUO Shaojuan, YANG Lixin. Toxic effects and mechanisms of exposure to single and mixture of mercury, cadmium, lead and arsenic[J]. Journal of Environmental Engineering Technology, 2018, 8(2): 221-230. doi: 10.3969/j.issn.1674-991X.2018.02.030
Citation: ZENG Chen, GUO Shaojuan, YANG Lixin. Toxic effects and mechanisms of exposure to single and mixture of mercury, cadmium, lead and arsenic[J]. Journal of Environmental Engineering Technology, 2018, 8(2): 221-230. doi: 10.3969/j.issn.1674-991X.2018.02.030

汞、镉、铅、砷单一和混合暴露的毒性效应及机理研究进展

doi: 10.3969/j.issn.1674-991X.2018.02.030
详细信息
    作者简介:

    曾晨(1992—),女,硕士,主要从事毒理学研究,zengchenx@163.com

    通讯作者:

    杨立新 E-mail: yanglx@craes.org.cn

  • 中图分类号: X171.5

Toxic effects and mechanisms of exposure to single and mixture of mercury, cadmium, lead and arsenic

More Information
    Corresponding author: Lixin YANG E-mail: yanglx@craes.org.cn
  • 摘要: 汞、镉、铅和砷是自然界中毒性较强的金属,镉和砷已确定为致癌物,汞和铅为可能致癌物。人类活动过程的排放是汞、镉、铅和砷的主要污染来源,由这些金属污染物暴露导致的人类疾病已经引起了公众的广泛关注。研究汞、镉、铅和砷在环境中实际暴露水平,尤其是汞、镉、铅和砷复合暴露对人体健康和生态环境影响及毒性效应的机理极为重要。根据暴露途径、暴露剂量和暴露时间,汞、镉、铅和砷具有不同的代谢途径,产生不同的毒性效应,具有不同的毒性效应机理。在总结现有汞、镉、铅、砷单一和混合暴露的健康损害及毒性效应的基础上,回顾、归纳汞、镉、铅和砷诱导产生毒性效应的机理,讨论基因组、转录组、蛋白质组和代谢组学等技术在汞、镉、铅和砷单一、混合毒性效应及机理研究中的应用并探讨 来的研究方向。

     

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  • 收稿日期:  2017-09-27
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