Abstract: Taking Beijing-Tianjin-Hebei region as the research area, the formation and dissipation process of atmospheric heavy polluted weather from November 17, 2014 to November 23, 2014 were analyzed by HYSPLIT model, combined with the ground meteorological monitoring data and aerial observations data, and the meteorological factors were analyzed. The results show that during the formation of heavy polluted weather in Beijing-Tianjin-Hebei, it is mainly at high pressure or uniform pressure state, the atmosphere is stable, and the atmosphere mixing layer is lower and facilitate to form static and stable weather. At the same time, the high humidity, high pressure, weak wind and inversion in the troposphere will suppress the convection of the water vapor and pollutants and cause them unable to spread obviously. The HYSPLIT model was used to simulate the flow back trajectory of 300 m height in Beijing, and the representative route of air mass trajectory was analyzed by cluster analysis method, which was compared with the ground meteorological monitoring data and aerial observations. The analysis shows that in the extreme weather conditions, the air pollution in Beijing-Tianjin-Hebei region is 80% affected by the southwest air flow, and the transportation trajectory of air pollutant is mainly from south to north. The dissipation process of atmospheric heavy pollution weathers in Beijing-Tianjin-Hebei region is 90% affected by the northern air currents. The rapid entry of the northern airflow will quickly dissipate the pollutants.