Abstract: Under the process conditions of 160-200 ℃ and 2 MPa initial pressure, using moderate oxidation drying (MOD) technology to perform harmless and reduction treatment for the antibiotic residues of Penicillin and Cephalosporin. The results showed that the antibiotics in the treated solid phases and residual liquids were not detected. The water content in the solid phase decreased from 80% to 40% or less and the quantity of antibiotic residue was reduced by 90%, and the calorific value of the antibiotic residue after treatment was 5 174-6 313 kJ/kg, all meeting with the requirements of the average low calorific value of garbage into the incinerator in the Technical Policy for Treatment and Prevention of Municipal Solid Waste. After the MOD treatment, the antibiotic residues were incinerated under 850 ℃. The results showed that the polycyclic aromatic hydrocarbons and antibiotics residues in the incineration residues were not detected, which indicated that the organic matter and antibiotics in the residue were completely decomposed. There was an enrichment of non-volatile heavy metals in the residue, so follow-up treatment must be strengthened. The concentration of SO₂ in the flue gas was relatively low, with an average concentration of less than 12 mg/m ³; the concentration of nitrogen oxides in the flue gas was slightly higher, and the subsequent tail gas treatment should be strengthened.