Abstract: Perfluorooctane sulfonate (PFOS) and perfluorooctane sulfonyl fluoride (PFOSF) were listed in Stockholm Convention as the newly-controlled persistent organic pollutants (POPs). As one of the member countries of this convention, China is currently the main country producing PFOS and is actively responding to PFOS reductions. There are many types of PFOS products, which are widely used in industry, lack of substitutes, so it is difficult to control PFOS industry. Therefore, how to implement the control of PFOS production industry is the key to achieve the source reduction of the PFOS performance target. By investigating the current situation of PFOS/PFOSF production industry and identifying the key nodes of PFOS production and emission, the cleaner production management system of PFOS production industry was analyzed. Two aspects of the development of the cleaner production technology were put forward, including the development of related product substitutes in PFOS production industry and the promotion of the cleaner production level in the existing industry. The cleaner production policy means to achieve PFOSF/PFOS performance targets was also proposed.