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大气颗粒物对斑马鱼胚胎的毒性及机制研究进展

郭少娟 张元元 王菲菲 杨立新

郭少娟, 张元元, 王菲菲, 杨立新. 大气颗粒物对斑马鱼胚胎的毒性及机制研究进展[J]. 环境工程技术学报, 2020, 10(3): 338-345. doi: 10.12153/j.issn.1674-991X.20190155
引用本文: 郭少娟, 张元元, 王菲菲, 杨立新. 大气颗粒物对斑马鱼胚胎的毒性及机制研究进展[J]. 环境工程技术学报, 2020, 10(3): 338-345. doi: 10.12153/j.issn.1674-991X.20190155
GUO Shaojuan, ZHANG Yuanyuan, WANG Feifei, YANG Lixin. A review of toxicity and mechanism of atmospheric particulate matter on zebrafish embryos[J]. Journal of Environmental Engineering Technology, 2020, 10(3): 338-345. doi: 10.12153/j.issn.1674-991X.20190155
Citation: GUO Shaojuan, ZHANG Yuanyuan, WANG Feifei, YANG Lixin. A review of toxicity and mechanism of atmospheric particulate matter on zebrafish embryos[J]. Journal of Environmental Engineering Technology, 2020, 10(3): 338-345. doi: 10.12153/j.issn.1674-991X.20190155

大气颗粒物对斑马鱼胚胎的毒性及机制研究进展

doi: 10.12153/j.issn.1674-991X.20190155
详细信息
    作者简介:

    郭少娟(1984—),女,硕士,主要从事分子生物学研究,guosj@craes.org.cn

    通讯作者:

    王菲菲 E-mail: wangff@craes.org.cn

  • 中图分类号: X171.5

A review of toxicity and mechanism of atmospheric particulate matter on zebrafish embryos

More Information
    Corresponding author: WANG Feifei E-mail: wangff@craes.org.cn
  • 摘要: 流行病学研究揭示PM2.5暴露与低体重新生儿,早产,先兆子痫,自发性流产,胎儿心血管、消化和神经系统发育异常以及出生缺陷具有相关性,但PM2.5对儿童发育影响的毒性机制尚不清楚。斑马鱼现已成为体内发育毒性研究的主要模式动物,综述了大气颗粒物对斑马鱼胚胎的毒性及机制相关研究进展,结果表明:大气颗粒物暴露可增加胚胎畸形率和死亡率,且效应强度与颗粒物来源和暴露方式有关;大气颗粒物还可造成胚胎骨骼、心脏、鱼鳔、肝、肠、肌肉等器官组织损伤;毒性机制主要包括改变胚胎全基因表达、microRNA表达及心脏AhR和Wnt/β-catenin通路相关基因表达,最终引起炎症和氧化应激过程,导致胚胎毒性和器官畸形,影响心血管、神经、运动等系统发育。

     

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出版历程
  • 收稿日期:  2019-09-02
  • 刊出日期:  2020-05-20

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