留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

四环素类抗生素环境行为及其生态毒性研究进展

敖蒙蒙 魏健 陈忠林 刘利 宋永会

敖蒙蒙, 魏健, 陈忠林, 刘利, 宋永会. 四环素类抗生素环境行为及其生态毒性研究进展[J]. 环境工程技术学报, 2021, 11(2): 314-324. doi: 10.12153/j.issn.1674-991X.20200096
引用本文: 敖蒙蒙, 魏健, 陈忠林, 刘利, 宋永会. 四环素类抗生素环境行为及其生态毒性研究进展[J]. 环境工程技术学报, 2021, 11(2): 314-324. doi: 10.12153/j.issn.1674-991X.20200096
AO Mengmeng, WEI Jian, CHEN Zhonglin, LIU Li, SONG Yonghui. Research progress on environmental behaviors and ecotoxicity of tetracycline antibiotics[J]. Journal of Environmental Engineering Technology, 2021, 11(2): 314-324. doi: 10.12153/j.issn.1674-991X.20200096
Citation: AO Mengmeng, WEI Jian, CHEN Zhonglin, LIU Li, SONG Yonghui. Research progress on environmental behaviors and ecotoxicity of tetracycline antibiotics[J]. Journal of Environmental Engineering Technology, 2021, 11(2): 314-324. doi: 10.12153/j.issn.1674-991X.20200096

四环素类抗生素环境行为及其生态毒性研究进展

doi: 10.12153/j.issn.1674-991X.20200096
详细信息
    作者简介:

    敖蒙蒙(1996—),女,硕士研究生,研究方向为持久性有机污染物控制技术, aomm9612@163.com

    通讯作者:

    陈忠林 E-mail: 836764633@qq.com

    宋永会 E-mail: songyh@craes.org.cn

  • 中图分类号: X703

Research progress on environmental behaviors and ecotoxicity of tetracycline antibiotics

More Information
    Corresponding author: CHEN Zhonglin E-mail: 836764633@qq.com; SONG Yonghui E-mail: songyh@craes.org.cn
  • 摘要: 四环素类抗生素(TCs)是目前世界上应用最广泛的抗生素种类之一,由于该类化合物不易被生物体吸收,难以在环境中降解,且在常规的污水处理系统中难以彻底去除,对生态系统和人类健康造成严重威胁。梳理分析了环境中TCs的来源及污染现状,详细阐述了其在环境中的迁移转化和降解,并对其引起的生态毒性效应进行了总结,指出了该类污染物的生态风险;对未来的研究进行了展望,提出TCs的环境行为应从环境多介质层面进行分析,同时加强对TCs生态毒性机理及其与其他环境污染物的联合毒性效应的研究。

     

  • [1] MEYET M T, BUMGARNER J E, VARMS J L, et al. Use of radioimmunoassay as a screen for antibiotics in confined animal feeding operations and confirmation by liquid chromatography/masss pectrometry[J]. Science of the Total Environment, 2000,248:181-187.
    [2] OKA H, ITO Y, MASTSUMOTO H J. Chromatographic analysis of tetracycline antibiotics in foods[J]. Journal of Chromatography A, 2000,882:109-33.
    [3] QIANG Z, ADAMS C. Potentiometric determination of acid dissociation constants (pKa) for human and veterinary antibiotics[J]. Water Research, 2004,38:2874-2890.
    [4] SASSMAN S A, LEE L S. Sorption of three tetracyclines by several soils: assessing the role of pH and canon exchange[J]. Environmental Science Technology, 2005,39:7452-7459.
    pmid: 16245815
    [5] FIGUEROA R A, LEONARD A, MACKAY A A. Modeling tetracycline antibiotic sorption to clays[J]. Environmental Science Technology, 2004,38:476-483.
    [6] ROSI-MARSHALL E J, KELLY J J. Antibiotic stewardship should consider environmental fate of antibiotics[J]. Environmental Science & Technology, 2015,49(9):5257-5258.
    [7] KOLPIN D W, FURLONG E T, MEYER M T, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams,1999-2000:a national reconnaissance[J]. Environmental Science & Technology, 2002,36(6):1202-1211.
    doi: 10.1021/es011055j
    [8] AWAD Y M, KIM S C, El-AZEEM S A M A, et al. Veterinary antibiotics contamination in water,sediment,and soil near a swine manure composting facility[J]. Environmental Earth Sciences, 2014,71(3):1433-1440.
    [9] CHEN K, ZHOU J L. Occurrence and behavior of antibiotics in water and sediments from the Huangpu River,Shanghai,China[J]. Chemosphere, 2014,95(5):604-612.
    [10] 武旭跃, 邹华, 朱荣, 等. 太湖贡湖湾水域抗生素污染特征分析与生态风险评价[J]. 环境科学, 2016,37(12):4596-4604.

    WU X Y, ZOU H, ZHU R, et al. Occurrence,distribution and ecological risk of antibiotics in surface water of the Gonghu Bay,Taihu Lake[J]. Environmental Science, 2016,37(12):4596-4604.
    [11] ANGELA L B, IAN B B, DIANA S A. Evaluating the vulnerability of surface waters to antibiotic contamination from varying wastewater treatment plant discharges[J]. Environmental Pollution, 2006,142(2):295-302.
    [12] GUO X Y, LÜ X J, ZHANG A G, et al. Antibiotic contamination in a typical water-rich city in Southeast China:a concern for drinking water resource safety[J]. Pesticides,Food Contaminants,and Agricultural Wastes, 2020,55(3):193-209.
    [13] 胡冠九, 陈素兰, 穆肃, 等. 江苏省某市典型饮用水水源中抗生素质量浓度特征[J]. 水资源保护, 2016,32(3):84-88.

    HU G J, CHEN S L, MU S, et al. Characteristics of concentrations of antibiotics in typical drinking water sources in a city in Jiangsu Province[J]. Water Resources Protection, 2016,32(3):84-88.
    [14] 王莹. 安徽部分饮用水源及污水9种抗生素的污染分布特征[D]. 合肥:安徽农业大学, 2012.
    [15] 唐俊, 陈海燕, 史陶中, 等. 巢湖喹诺酮及四环素类药物污染现状及来源分析[J]. 安徽农业大学学报, 2013,40(6):1043-1048.

    TANG J, CHEN H Y, SHI T Z, et al. Occurrence of quinolones and tetracyclines antibiotics in the aquatic environment of Chaohu Lake[J]. Journal of Anhui Agricultural University, 2013,40(6):1043-1048.
    [16] 周志峰, 李学云, 李可, 等. 深圳地区主要河流抗生素污染调查与溯源分析[J]. 现代预防医学, 2019,46(17):3120-3125.

    ZHOU Z F, LI X Y, LI K, et al. Investigation and traceability analysis of antibiotic pollution in main rivers,Shenzhen[J]. Modern Preventive Medicine, 2019,46(17):3120-3125.
    [17] 刘虹, 张国平, 刘丛强. 固相萃取-色谱测定水、沉积物及土壤中氯霉素和3种四环素类抗生素[J]. 分析化学, 2007,35(3):315-319.

    LIU H, ZHANG G P, LIU C Q. Determination of chloramphenicol and three tetracyclines by solid phase extraction and high performance liquid chromatography-ultraviolet detection[J]. Chinese Journal of Analytical Chemistry, 2007,35(3):315-319.
    [18] MATSUIA Y, OZUB T. Occurrence of a veterinary antibiotic in streams in a small catchment area with livestock farms[J]. Desalination, 2008,226(1):215-221.
    [19] 阮悦斐, 陈继淼, 郭昌胜, 等. 天津近郊地区淡水养殖水体的表层水及沉积物中典型抗生素的残留分析[J]. 农业环境科学学报, 2011,30(12):2586-2593.

    RUAN Y F, CHEN J M, GUO C S, et al. Distribution characteristics of typical antibiotics in surface water and sediments from freshwater areas,China[J]. Journal of Agro-Environment Science, 2011,30(12):2586-2593.
    [20] 姜蕾, 陈书怡, 杨蓉, 等. 长江三角洲地区典型废水中抗生素的初步分析[J]. 环境化学, 2008,27(3):371-374.

    JIANG L, CHEN S Y, YANG R, et al. Occurrence of antibiotics in the aquatic environment of the Changjiang Delta,China[J]. Environmental Chemistry, 2008,27(3):371-374.
    [21] PAN X, QIANG Z M, BEN W W, et al. Simultaneous determination of three classes of antibiotics in the suspended solids of swine wastewater by ultrasonic extraction, solid-phase extraction and liquid chromatography-mass spectrometry[J]. Journal of Environmental Sciences, 2011,23(10):1729-1737.
    [22] 魏瑞成, 葛峰, 陈明, 等. 江苏省畜禽养殖场水环境中四环类抗生素污染研究[J]. 农业环境科学学报, 2010,29(6):1205-1210.

    WEI R C, GE F, CHEN M, et al. Pollution of tetracyclines from livestock and poultry farms in aquatic environment in Jiangsu Province,China[J]. Journal of Agro-Environment Science, 2010,29(6):1205-1210.
    [23] 陈永山, 章海波, 骆永明, 等. 典型规模化养猪场废水中兽用抗生素污染特征与去除效率研究[J]. 环境科学学报, 2010,30(11):2205-2212.
    [24] 国彬, 姚丽贤, 刘忠珍, 等. 广州市兽用抗生素的环境残留研究[J]. 农业环境科学学报, 2011,30(5):938-945.

    GUO B, YAO L X, LIU Z Z, et al. Environmental residues of veterinary antibiotics in Guangzhou City,China[J]. Journal of Agro-Environment Science, 2011,30(5):938-945.
    [25] BATT A L, BRUCE I B, AGA D S. Evaluating the vulnerability of surface water to antibiotic contamination from varying wastewater treatment plant discharges[J]. Environmental Pollution, 2006,142(2):295-302.
    pmid: 16324772
    [26] HIRSCH R, THOMAS A T, HABERER K, et al. Determination of antibiotics in different water compartments via liquid chromatography-electrospray tandem mass spectrometry[J]. Journal of Chromatography A, 1998,815(2):213-223.
    [27] GAO P, MARIYA M, IRENE X. Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant[J]. Science of the Total Environment 2012,421/422:173-183.
    [28] 那广水, 陈彤, 张月梅, 等. 中国北方地区水体中四环素族抗生素残留现状分析[J]. 中国环境监测, 2009,25(6):78-80.

    NA G S, CHEN T, ZHANG Y M, et al. Analysis terracyclines antibiotics residues status in water of North China[J]. Environmental Monitoring in China, 2009,25(6):78-80.
    [29] 彭艳, 丁世敏, 刘蕖, 等. 水环境中抗生素的光化学降解研究进展[J]. 广州化工, 2016,44(10):14-17.

    PENG Y, DING S M, LIU Q, et al. Research progress on photochemical degradation of antibiotics in water environment[J]. Guangzhou Chemical Industry, 2016,44(10):14-17.
    [30] 刘冲, 黄满红, 肖斌. 城市污水厂中四环素类抗生素分布特性研究[J]. 广州化工, 2012,40(14):153-156.

    LIU C, HUANG M H, XIAO B. Determination of the distribution characteristics of tetracyclines in wastewater treatment plant[J]. Guangzhou Chemical Industry, 2012,40(14):153-156.
    [31] YANG S, CARLSON K. Evolution of antibiotic occurrence in a river through pristine, urban and agricultural landscapes[J]. Water Research, 2003,37(19):4645-4656.
    [32] PAWELZICK H T, HOPER H, NAU H, et al. A survey of the occurrence of various tetracyclines and sulfamethazine in sandy soils in Northwestern Germany fertilized with liquid manure[J]. Czech Republic, 2004: 18-22.
    [33] LALUMERA G M, CALAMARI D, GALLI P, et al. Preliminary investigation on the environmental occurrence and effects of antibiotics used in aquaculture in Italy[J]. Chemosphere, 2004,54(5):661-668.
    doi: 10.1016/j.chemosphere.2003.08.001 pmid: 14599512
    [34] AJIT K S, MICHAEL T, MEYER ,et al.A global perspective on the use,sales,exposure pathways,occurrence, fate and effects of veterinary antibiotics (VAs) in the environment[J]. Chemosphere, 2006,65(5):725-759.
    doi: 10.1016/j.chemosphere.2006.03.026 pmid: 16677683
    [35] RAHMAN M M, SHAN J, YANG P, et al. Effects of long-term pig manure application on antibiotics,abundance of antibiotic resistance genes (ARGs),anammox and denitrification rates in paddy soils[J]. Environmental Pollution, 2018,240:368-377.
    pmid: 29753245
    [36] 李彦文, 莫测辉, 赵娜, 等. 菜地土壤中磺胺类和四环素类抗生素污染特征研究[J]. 环境科学, 2009,30(6):1762-1766.

    LI Y W, MO C H, ZHAO N, et al. Investigation of sulfonamides and tetracyclines antibiotics in soils from various vegetable fields[J]. Environmental Science, 2009,30(6):1762-1766.
    [37] 张涛, 郭晓, 刘俊杰, 等. 江西梅江流域土壤中四环素类抗生素的含量及空间分布特征[J]. 环境科学学报, 2017,37(4):1493-1501.

    ZHANG T, GUO X, LIU J J, et al. Concentration and spatial distribution of tetracycline antibiotics in soil of Meijiang River Catchment,Jiangxi Province[J]. Acta Scientiae Circumstantiae, 2017,37(4):1493-1501.
    [38] 朱秀辉, 曾巧云, 解启来, 等. 广州市北郊蔬菜基地土壤四环素类抗生素的残留及风险评估[J]. 农业环境科学学报, 2017,36(11):2257-2266.

    ZHU X H, ZENG Q Y, XIE Q L, et al. Residues and risk assessment of tetracycline antibiotics in vegetable-growing soils from suburban areas of northern Guangzhou[J]. Journal of Agro-Environment Science, 2017,36(11):2257-2266.
    [39] 孙刚. 畜禽粪便中四环素类抗生素检测分析及其在堆肥中的降解研究[D]. 合肥:合肥工业大学. 2010.
    [40] 刘新程, 董元华, 王辉. 江苏省集约化养殖畜禽排泄物中四环素类抗生素残留调查[J]. 农业环境科学学报, 2008,27(3):1177-1182.

    LIU X C, DONG Y H, WANG H. Residues of tetracyclines in animal manure from intensive farm in Jiangsu Province[J]. Journal of Agro-Environment Science, 2008,27(3):1177-1182.
    [41] 罗方园, 潘根兴, 李恋卿, 等. 洪泽湖沉积物中四环素土霉素及相关抗性基因的分布特征及潜在风险分析[J]. 农业环境科学学报, 2017,36(2):369-375.

    LUO F Y, PAN G X, LI L Q, et al. The distribution characteristics and potential risk of tetracycline,oxytetracycline and their corresponding genes pollution in sediment of Hongze Lake[J]. Journal of Agro-Environment Science, 2017,36(2):369-375.
    [42] ZHANG Q Q, YING G G, PAN C G, et al. Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance[J]. Environmental Science & Technology, 2015,49(11):6772-6782.
    [43] ZHOU L J, YING G G, ZHAO J L, et al. Trends in the occurrence of human and veterinary antibiotics in the sediments of the Yellow River,Hai River and Liao River in Northern China[J]. Environmental Pollution, 2011,159(7):1877-1885.
    pmid: 21501908
    [44] 刘虹, 张国平, 刘丛强, 等. 贵阳城市污水及南明河中氯霉素和四环素类抗生素的特征[J]. 环境科学, 2009,30(3):687-692.

    LIU H, ZHANG G P, LIU C Q, et al. Characteristics of chloramphenicol and tetracyclines in municipal sewage and Nanming River of Guiyang City,China[J]. Environmental Science, 2009,30(3):687-692.
    [45] 杨媛. 新疆巴州地区水环境中多种抗生素的浓度水平与分布特征[D]. 石河子:石河子大学, 2018.
    [46] TOLLS J. Sorption of veterinary pharmaceuticals in soils:a review[J]. Environmental Science & Technology, 2001,35:3397-3406.
    [47] SASSMAN S A, LEE L S. Sorption of three tetracyclines by several soils: assessing the role of ph and cation exchange[J]. Environmental Science & Technology, 2005,39(19):7452-7459.
    doi: 10.1021/es0480217 pmid: 16245815
    [48] 章明奎, 王丽平, 郑顺安. 两种外源抗生素在农业土壤中的吸附与迁移特性[J]. 生态学报, 2008,28(2):761-766.

    ZHANG M K, WANG L P, ZHENG S A. Adsorption and transport characteristics of two exterior-source antibiotics in some agricultural soils Acta Ecologica Sinica 2008,28(2):761-766.
    [49] 王冉, 刘铁铮, 王恬. 抗生素在环境中的转归及其生态毒性[J]. 生态学报, 2006,26(1):265-270.

    WANG R, LIU T Z, WANG T. The fate of antibiotics in environment and its ecotoxicology:a review[J]. Acta Ecologica Sinica, 2006,26(1):265-270.
    [50] 鲍艳宇, 周启星, 鲍艳姣, 等. 3种四环素类抗生素在石油污染土壤上的吸附解吸[J]. 中国环境科学, 2012,32(7):1257-1262.

    BAO Y Y, ZHOU Q X, BAO Y J, et al. Adsorption and desorption of three tetracycline antibiotics in petroleum-contaminated soils[J]. China Environmental Science, 2012,32(7):1257-1262.
    [51] 武庭瑄, 周敏, 郭宏栋, 等. 四环素在黄土中的吸附行为[J]. 环境科学学报, 2008,28(11):2311-2314.

    WU T X, ZHOU M, GUO H D, et al. Adsorption of tetracycline on loess soils[J]. Acta Scientiae Circumstantiae, 2008,28(11):2311-2314.
    [52] ELENA M C, CARMEN G B, SCHARF S, et al. Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria[J]. Environmental Pollution, 2007,148(2):570-579.
    [53] ZHANG Z Y, SUN K, GAO B, et al. Adsorption of tetracycline on soil and sediment:effects of pH and the presence of Cu(Ⅱ)[J]. Journal of Hazardous Materials, 2011,190(1/2/3):856-862.
    [54] 杨桂朋, 孙晓春. 海水中农药的光化学降解研究[J]. 中国海洋大学学报(自然科学版), 2007,37(4):550-556.

    YANG G P, SUN X C. Studies on photodegradation of pesticides in seawater[J]. Periodical of Ocean University of China, 2007,37(4):550-556.
    [55] 李伟明, 鲍艳宇, 周启星. 四环素类抗生素降解途径及其主要降解产物研究进展[J]. 应用生态学报, 2012,23(8):2300-2308.

    LI W M, BAO Y Y, ZHOU Q X. Degradation pathways and main degradation products of tetracycline antibiotics:research progress[J]. Chinese Journal of Applied Ecology, 2012,23(8):2300-2308.
    [56] JIAO S J, ZHENG S R, YIN D Q, et al. Aqueous photolysis of tetracycline and toxicity of photolytic products to luminescent bacteria[J]. Chemosphere, 2008,73(3):377-382.
    doi: 10.1016/j.chemosphere.2008.05.042 pmid: 18617218
    [57] REYES C, FERNANDEZ J, FREER J, et al. Degradation and inactivation of tetracycline by TiO2 photocatalysis[J]. Journal of Photochemistry and Photobiology Biology, 2006,184(1/2):141-146.
    [58] DOI A M, STOSKOPF M K. The kinetcs of oxytetracycline degradation in deionized water under varying temperature,pH,light,substrate,and organic matter[J]. Journal of Aquatic Animal Health, 2000,12(3):246-253.
    [59] XUAN R C, ARIST L, WANG Q Q, et al. Hydrolysis and photolysis of oxytetracycline in aqueous solution[J]. Journal of Environmental Science and Health Part B, 2010,45:73-81.
    [60] 张杏艳, 陈中华, 邓海明, 等. 水环境中四环素类抗生素降解及去除研究进展[J]. 生态毒理学报, 2016,11(6):44-52.

    ZHANG X Y, CHEN Z H, DENG H M, et al. A review on degradation and elimination of tetracycline antibiotics in water environment[J]. Asian Journal of Ecotoxicology, 2016,11(6):44-52.
    [61] 郑丽英. 金霉素的水解动力学研究[J]. 广州化工, 2010,38(12):182-183.

    ZHENG L Y. Hydrolysis kinetics of the chlortetracycline[J]. Guangzhou Chemical Industry, 2010,38(12):182-183.
    [62] LOFTIN K A, ADAMS C D, MEYER M T, et al. Effects of ionic strength,temperature, and pH on degradation of selected antibiotics[J]. Journal of Environment Quality, 2008,37(2):378.
    doi: 10.2134/jeq2007.0230
    [63] 张志旭. 四环素在粘土矿中的吸附及降解机制研究[D]. 长沙:湖南农业大学, 2018.
    [64] USLU M O, BALCIUGLU I A. Ozonation of animal wastes containing oxytetracycline[J]. Ozone:Science & Engineering, 2008,30(4):290-299.
    [65] WU J G, JIANG Y X, ZHA L Y, et al. Tetracycline degradation by ozonation, and evaluation of biodegradability and toxicity of ozonation byproducts[J]. Canadian Journal of Civil Engineering, 2010,37(11):1485-1491.
    [66] WANG Y, ZHANG H, ZHANG J H, et al. Degradation of tetracycline in aqueous media by ozonation in an internal loop-lift reactor[J]. Journal of Hazardous Materials, 2011,192(1):35-43.
    pmid: 21616591
    [67] 李国亭, 郭宇杰, 汪宁改, 等. 高锰酸钾降解四环素的过程研究[J]. 华北水利水电学院学报(社会科学版), 2009,30(5):77-79.

    LI G T, GUO Y J, WANG N G, et al. Study on the degradation process of tetracycline by potassium permanganate[J]. Journal of North China University of Water Resources and Electric Power (Social Sciences Edition), 2009,30(5):77-79.
    [68] 刘伟, 王慧, 陈小军, 等. 抗生素在环境中降解的研究进展[J]. 动物医学进展, 2009,30(3):89-94.

    LIU W, WANG H, CHEN X J, et al. Progress on degradation of antibiotics in environment[J]. Progress in Veterinary Medicine, 2009,30(3):89-94.
    [69] 张欣阳, 蔡婷静, 许旭萍. 一株高效四环素降解菌的分离鉴定及其降解性能研究[J]. 生物技术通报, 2015,31(1):173-180.

    ZHANG X Y, CAI T J, XU X P. Isolation and identification of a tetracycline-degrading bacterium and optimizing condition for tetracycline degradation[J]. Biotechnology Bulletin, 2015,31(1):173-180.
    [70] HUANG X, ZHANG X, FENG F, et al. Biodegradation of tetracycline by the yeast strain Trichosporon mycotoxinivorans XPY-10[J]. Preparative Biochemistry & Biotechnology, 2014,46(1):15-22.
    [71] MAKI T, HASEGAWA H, KITAMI H, et al. Bacterial degradation of antibiotic residues in marine fish farm sediments of Uranouchi Bay and phylogenetic analysis of antibiotic-degrading bacteria using 16S rDNA sequences[J]. Fisheries Science, 2006,72(4):811-820.
    [72] 许晓玲, 李卫芬, 雷剑, 等. 四环素降解菌的选育、鉴定及其降解特性[J]. 农业生物技术学报, 2011,19(3):549-556.

    XU X L, LI W F, LEI J, et al. Screening,identification and degradation characteristics of tetracycline-degrading strains[J]. Journal of Agricultural Biotechnology, 2011,19(3):549-556.
    [73] 成洁, 杜慧玲, 张天宝, 等. 四环素类抗生素降解菌的分离与鉴定[J]. 核农学报, 2017,31(5):884-888.

    CHENG J, DU H L, ZHANG T B, et al. Isolation and identification of tetracyclines degrading bacteria[J]. Journal of Nuclear Agricultural Sciences, 2017,31(5):884-888.
    [74] 张健, 关连珠. 猪粪中3种四环素类抗生素在土壤中的动态变化及降解途径[J]. 植物营养与肥料学报, 2013,19(3):727-732.

    ZHANG J, GUAN L Z. Dynamics and mechanism of degradation of three tetracycline antibiotics from pig manures in soil[J]. Journal of Plant Nutrition and Fertilizer, 2013,19(3):727-732.
    [75] 张树清, 张夫道, 刘秀梅, 等. 高温堆肥对畜禽粪中抗生素降解和重金属钝化的作用[J]. 中国农业科学, 2006,39(2):337-343.

    ZHANG S Q, ZHANG F D, LIU X M, et al. Degradation of antibiotics and passivation of heavy metals during thermophilic composting process[J]. Scientia Agricultura Sinica, 2006,39(2):337-343.
    [76] 秦莉, 高茹英, 李国学, 等. 外源复合菌系对堆肥纤维素和金霉素降解效果的研究[J]. 农业环境科学学报, 2009,28(4):820-823.

    QIN L, GAO R Y, LI G X, et al. Decomposition effect of additive of composite microbial system on cellulose and chlortetracycline in composting[J]. Journal of Agro-Environment Science, 2009,28(4):820-823.
    [77] KIRK J L, KLIRONOMOS J N, LEE H, et al. The effects of perennial ryegrass and alfalfa on microbial abundance and diversity in petroleum contaminated soil[J]. Environmental Pollution, 2005,133(3):455-465.
    doi: 10.1016/j.envpol.2004.06.002 pmid: 15519721
    [78] 陶美. 四环素降解菌筛选及其降解特性研究[D]. 成都:西南交通大学, 2018.
    [79] 陈小洁, 李凤玉, 郝雅宾. 两种水生植物对抗生素污染水体的修复作用[J]. 亚热带植物科学, 2012,41(4):1-7.

    CHEN X J, LI F Y, HAO Y B. The preliminary exploration of remediation the antibiotics polluted water by two hydrophytes[J]. Subtropical Plant Science, 2012,41(4):1-7.
    [80] 廖杰, 徐熙安, 刘玉洪, 等. 水生植物滤床深度处理养殖废水过程中抗生素与抗性基因的响应研究[J]. 环境科学学报, 2015,35(8):2464-2470.

    LIAO J, XU X A, LIU Y H, et al. Removal and response of antibiotics and antibiotic resistance genes during advanced treatment of livestock wastewater by aquatic plant filter bed[J]. Acta Scientiae Circumstantiae, 2015,35(8):2464-2470.
    [81] KUMARA K, GUPTA S C, BAIDOO S K, et al. Antibiotic uptake by plants from soil fertilized with animal manure[J]. Journal of Environment Quality, 2005,34(6):2082.
    [82] BOLEAS S, ALONSO C, PRO J, et al. Toxicity of the antimicrobial oxytetracycline to soil organisms in a multi-species-soil system (MS·3) and influence of manure co-addition[J]. Journal of Hazardous Materials, 2005,122(3):233-241.
    doi: 10.1016/j.jhazmat.2005.03.003 pmid: 15967279
    [83] 张浩, 罗义, 周启星. 四环素类抗生素生态毒性研究进展[J]. 农业环境科学学报, 2008,27(2):407-413.

    ZHANG H, LUO Y, ZHOU Q X. Research advancement of eco-toxicity of tetracycline antibiotics[J]. Journal of Agro-Environment Science, 2008,27(2):407-413.
    [84] DIJCK P V, VOORDE H V D. Sensitivity of environmental microorganisms to antimicrobial agents[J]. Applied and Environmental Microbiology, 1976,31(3):332-336.
    pmid: 938030
    [85] 王丽平, 章明奎. 土霉素污染对土壤生物学性质影响的初步研究[J]. 农业环境科学学报, 2009,28(7):1434-1438.

    WANG L P, ZHANG M K. Effects of oxytetracycline pollution on soil biological properties[J]. Journal of Agro-Environment Science, 2009,28(7):1434-1438.
    [86] BACKHAUS T, GRIMME L H. The toxicity of antibiotic agents to the luminescent bacterium Vibrio fischeri[J]. Chemosphere, 1999,38(14):3291-3301.
    [87] THIELE-BEUHN S, BECKL I C. Effects of sulfonamide and tetracycline antibiotics on soil microbial activity and microbial biomass[J]. Chemosphere, 2005,59:457-465.
    [88] 张劲强, 梁岩, 董元华, 等. 差向异构对四环素类药物的发光菌毒性研究[J]. 毒理学杂志, 2006,20(5):279-281.

    ZHANG J Q, LIANG Y, DONG Y H, et al. Toxicity of tetracyclines and their epi-isomers on the luminescent bacterium[J]. Journal of Toxicology, 2006,20(5):279-281.
    [89] 王婧, 丁武, 边秀芳. 牛奶中土霉素对青海弧菌和费氏弧菌的毒性作用测定[J]. 中国奶牛, 2011(20):60-64.

    WANG J, DING W, BIAN X F. Determination method of Cliimycin in milk by using Vibrio qinghaiensis and Vibrio fischeri[J]. China Dairy Cattle, 2011(20):60-64.
    [90] 徐冬梅, 王艳花, 饶桂维. 四环素类抗生素对淡水绿藻的毒性作用[J]. 环境科学, 2013,34(9):3386-3390.

    XU D M, WANG Y H, RAO G W. Cellular response of freshwater green algae to the toxicity of tetracycline antibiotics[J]. Environmental Science, 2013,34(9):3386-3390.
    [91] HALLIING S B. Algal toxicity of antibacterial agents used in intensive farming[J]. Chemosphere, 2000,40(7):731-739.
    [92] GAGNE F, BLAISE C, FOURNINER M, et al. Effects of selected pharmaceutical products on phagocytic activity in Elliptio complanata mussels[J]. Comparative Biochemistry and Physiology Part C:Toxicology and Pharmacology, 2006,143(2):179-186.
    [93] KONG W D, ZHU Y G, LIANG Y C, et al. Uptake of oxytetracycline and its phytotoxicity to alfalfa (Medicago sativa L.)[J]. Environmental Pollution, 2007,147(1):187-193.
    [94] MAFFII G, MAINARDI L. Pharmacological study of a new antibiotic:tetracycline[J]. Farmaco,Edizione Scientifica, 1955,10(4):197-210.
    [95] TUBARO E, BANCI F. Influence of the modifications of the carboxamido group on the physico-chemical,pharmacological and clinical behavior of tetracycline[J]. Bollettino Chimico Farmaceutico, 1963,102:660-687.
    pmid: 14116464
    [96] GNANASOUNDARI M, PARI L. Impact of naringenin on oxytetracycline-mediated oxidative damage in kidney of rats[J]. Renal Failure, 2006,28(7):599-605.
    pmid: 17050244
    [97] 高利宏, 敖林, 胡冉, 等. 四环素致BALB/c小鼠肝脏毒性的基因表达谱研究[J]. 第三军医大学学报, 2006,28(6):494-498.

    GAO L H, AO L, HU R, et al. Gene expression profiles of toxicated BALB/c mouse liver exposed to tetracycline[J]. Acta Academiae Medicinae Militaris Tertiae, 2006,28(6):494-498.
    [98] 王慧珠, 罗义, 徐文青, 等. 四环素和金霉素对水生生物的生态毒性效应[J]. 农业环境科学学报, 2008,27(4):1536-1539.

    WANG H Z, Luo Y, XU W Q, et al. Ecotoxic effects of tetraycline and chlortetracycljne on aguatic organisms[J]. Journal of Agro-Environmental Sciences, 2008,27(4):1536-1539
    [99] 曲甍甍, 孙立伟, 陈鋆, 等. 兽药添加剂阿散酸和土霉素的毒理学研究[J]. 农业环境科学学报, 2004,23(2):240-242.

    QU M M, SUN L W, CHEN L, et al. Toxicigical characters of arsanilic acid and oxytetracycline[J]. Journal of Agro-Environmental Science, 2004,23(2):240-242.
    [100] 李兆利, 陈海刚, 徐韵, 等. 3种兽药及饲料添加剂对鱼类的毒理效应[J]. 生态与农村环境学报, 2006,22(1):84-86.

    LI Z L, CHEN H G, XU Y, et al. Toxicological effects of three veterinary drugs and feed additives on fish[J]. Journal of Ecology and Rural Environment, 2006,22(1):84-86.
    [101] BRADEL B G, PREIL W, JESKE H. Remission of the free-branching pattern of euphorbia pulcherrima by tetracycline treatment[J]. Journal of Phytopathology, 2000,148(11/12):587-590.
    [102] 张乙涵, 伍钧, 陈莉, 等. 基于植物根伸长终点测试四环素对植物的毒性阈值及其敏感性分布(SSD)[J]. 农业环境科学学报, 2014,33(2):243-249.

    ZHANG Y H, WU Y, CHEN L, et al. Toxicity thresholds of tetracycline to plants as determined by root elongation and its species sensitivity distributions[J]. Journal of Agro-Environment Science, 2014,33(2):243-249.
    [103] BATCHELDER A R. Chlortetracycline and oxytetracycline effects on plant growth and development in soil systems[J]. Journal of Environment Quality, 1982,11(4):515-518.
    [104] 马驿, 孙永学, 陈进军, 等. 兽药残留对生态环境影响的研究进展[J]. 中国兽医科学, 2010,40(6):650-654.

    MA Y, SUN Y X, CHEN J J, et al. Advance in ecological environment impact of veterinary drug residues[J]. Chinese Veterinary Science, 2010,40(6):650-654.
    [105] BAGUER A J, JENSEN J, KROGH P. Effects of the antibiotics oxytetracycline and tylosin on soil fauna[J]. Chemosphere, 2000,40(7):751-757.
    [106] YIN H Q, KIM M, KIM J H, et al. Hepatic gene expression profiling and lipid homeostasis in mice exposed to steatogenic drug,tetracycline[J]. Toxicological Sciences, 2006,94(1):206-216.
    doi: 10.1093/toxsci/kfl078 pmid: 16917069
    [107] FAROMBI E O, UGWUEZUNMBA M C, EZENWADU T T, et al. Tetracycline-induced reproductive toxicity in male rats:effects of vitamin C and N-acetylcysteine[J]. Experimental & Toxicologic Pathology, 2008,60(1):77-85.
    pmid: 18406588
    [108] 吴楠, 乔敏, 朱永官. 猪场土壤中5种四环素抗性基因的检测和定量[J]. 生态毒理学报, 2009,4(5):705-710.

    WU N, QIAO M, ZHU Y G. Quantification of five tetracycline resistance genes in soil from a swine feedlot[J]. Asian Journal of Ecotoxicology, 2009,4(5):705-710.
    [109] 张兰河, 王佳佳, 哈雪姣, 等. 北京地区菜田土壤抗生素抗性基因的分布特征[J]. 环境科学, 2016,37(11):4395-4401.

    ZHANG L H, WANG J J, HA X J, et al. Distribution characteristics of antibiotic resistance genes in vegetable soils in Beijing[J]. Environmental Science, 2016,37(11):4395-4401
    [110] DANG H Y, ZHANG X X, SONG L H, et al. Molecular characterizations of oxytetracycline resistant bacteria and their resistance genes from mariculture waters of China[J]. Marine Pollution Bulletin, 2006,52(11):1494-1503.
    doi: 10.1016/j.marpolbul.2006.05.011 pmid: 16828121
    [111] AGERSO Y, PETERSEN A. The tetracycline resistance determinant Tet 39 and the sulphonamide resistance gene sulII are common among resistant Acinetobacter spp. isolated from integrated fish farms in Thailand[J]. Journal of Antimicrobial Chemotherapy, 2006,59(1):23-27.
    [112] TAO R, YING G G, SU H C, et al. Detection of antibiotic resistance and tetracycline resistance genes in Enterobacteriaceae isolated from the Pearl Rivers in South China[J]. Environmental Pollution, 2010,158(6):2101-2109.
    [113] CHEE-SANFORD J C, AMINOV R I, KRAPAC I J, et al. Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities[J]. Applied and Environmental Microbiology, 2001,67(4):1494-1502.
    doi: 10.1128/AEM.67.4.1494-1502.2001 pmid: 11282596
    [114] AUERBACH E A, SEYFRIED E E, MCMAHON K D. Tetracycline resistance genes in activated sludge wastewater treatment plants[J]. Water Research, 2007,41(5):1143-1151.
    doi: 10.1016/j.watres.2006.11.045 pmid: 17239919
    [115] CIZMAS L, SHARMA V K, GRAY C M, et al. Pharmaceuticals and personal care products in waters: occurrence, toxicity,and risk[J]. Environmental Chemistry Letters, 2015,13(4):381-394.
  • 加载中
计量
  • 文章访问数:  1588
  • HTML全文浏览量:  340
  • PDF下载量:  303
  • 被引次数: 0
出版历程
  • 收稿日期:  2020-04-24
  • 刊出日期:  2021-03-20

目录

    /

    返回文章
    返回