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吸入暴露途径下纳米塑料在SD大鼠体内的富集特征研究

董小艳 杨波 谢颖 李明姣 陈嘉禾 李浩然 阮鸿洁 王琼

董小艳,杨波,谢颖,等.吸入暴露途径下纳米塑料在SD大鼠体内的富集特征研究[J].环境工程技术学报,2024,14(3):764-768 doi: 10.12153/j.issn.1674-991X.20240109
引用本文: 董小艳,杨波,谢颖,等.吸入暴露途径下纳米塑料在SD大鼠体内的富集特征研究[J].环境工程技术学报,2024,14(3):764-768 doi: 10.12153/j.issn.1674-991X.20240109
DONG X Y,YANG B,XIE Y,et al.Study on the accumulation characteristics of nanoplastics in SD rats under inhalation exposure route[J].Journal of Environmental Engineering Technology,2024,14(3):764-768 doi: 10.12153/j.issn.1674-991X.20240109
Citation: DONG X Y,YANG B,XIE Y,et al.Study on the accumulation characteristics of nanoplastics in SD rats under inhalation exposure route[J].Journal of Environmental Engineering Technology,2024,14(3):764-768 doi: 10.12153/j.issn.1674-991X.20240109

吸入暴露途径下纳米塑料在SD大鼠体内的富集特征研究

doi: 10.12153/j.issn.1674-991X.20240109
基金项目: 国家自然科学基金项目(42177418)
详细信息
    作者简介:

    董小艳(1974—),女,研究员,主要从事环境卫生与健康研究,dongxiaoyan@nieh.chinacdc.cn

    通讯作者:

    王琼(1982—),女,副研究员,主要从事环境污染与健康研究,wangqiong@nieh.chinacdc.cn

  • 中图分类号: X50

Study on the accumulation characteristics of nanoplastics in SD rats under inhalation exposure route

  • 摘要:

    为探讨吸入暴露纳米级塑料在生物体呼吸系统以外组织上的富集特征,以100 nm聚苯乙烯微球对SD大鼠进行2 h短期吸入暴露,使用热裂解-气相色谱质谱法测定大鼠肝脏、肾脏、心脏以及脑组织上的聚苯乙烯浓度。结果显示:暴露组大鼠肾脏、心脏和肝脏中的浓度〔(0.416±0.143)、(0.633±0.278)和(0.617±0.179)g/g〕显著高于对照组大鼠〔(0.249±0.020)、(0.070±0.096)和(0.101±0.140)g/g〕,差异具有统计学意义(P<0.05),但各组织间的相关性不显著(P>0.05);2组大鼠脑组织均未检出聚苯乙烯。研究表明,100 nm聚苯乙烯微球吸入暴露2 h后,可通过肺泡进入血液循环,进而在大鼠肝脏、肾脏、心脏中形成沉积。通过探讨纳米级塑料在生物体内的累积特征,为深入开展吸入纳米塑料对人体的健康影响研究提供数据支撑。

     

  • 图  1  吸入暴露100 nm PS-NPs后其在大鼠不同组织上分布特征

    注:*表示P<0.05。

    Figure  1.  Distribution of 100 nm PS-NPs via inhalation in different tissues of rats

    图  2  暴露组各组织之间PS-NPs浓度的相关性(n=6)

    Figure  2.  Correlation of PS-NPs in different tissues of the exposed group

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出版历程
  • 收稿日期:  2024-02-25
  • 录用日期:  2024-04-02
  • 修回日期:  2024-03-23

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