Abstract: To explore veterinary antibiotics pollution, the amounts of produced manure and used antibiotics in livestock and poultry breeding in Beijing-Tianjin-Hebei(BTH) region were estimated. It was illustrated that the manure production amount of livestock and poultry in BTH region was lower in northwest and higher in southeast, which was mainly caused by geographic reason and regional development planning. The antibiotic amounts used in livestock and poultry breeding for BTH region were ranked as: tetracyclines>macrolides>diterpenoids>sulfonamides>β-lactams>aminoglycosides>fluoroquinolones, in which tetracyclines usage amount is much higher than other classes. In addition, the residue levels of antibiotics in manure and farmland in BTH region were summarized through literature reviews. It was found that detection frequency and detection concentration of antibiotics in manure and wastewater were very high, especially for tetracyclines, the concentrations of which were much higher than those of sulfonamides or β-lactams. Many antibiotics have been detected in farmland with manure application in BTH region, and the concentrations were significantly higher than those in the farmland without manure application. Finally, considering the antibiotics pollution of livestock and poultry breeding in BTH region, some advices were proposed, including decreasing antibiotics usage amount, developing compost treatment of manure for antibiotics removal, and promoting layout optimization of livestock and poultry breeding in BTH region.